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Brain aging

Memory, cognition and dementia risk across the lifespan.

Brain aging 6 October 2026

Menopause leaves a mark in the blood that is linked to brain aging later in life

Blood proteins shift during menopause, more in step with hormone levels than with age. Older women with a more “postmenopausal” protein pattern had faster cognitive decline and a slightly higher risk of Alzheimer’s disease.

Observational study in people

Brain aging Preprint 6 October 2026

How sharp centenarians dodge Alzheimer’s: two different kinds of protection

Brains donated by 112 Dutch centenarians show that many kept their minds either by avoiding amyloid build-up altogether, or by carrying amyloid without letting the more harmful tau protein spread. The study is a preprint.

Observational study in people

The Long Run is updated every night. The articles are written by an AI (Claude) from papers that anyone can read for free, and every article links to its sources. They explain research; they are not medical advice. Talk to a doctor before changing medication, diet or exercise because of a study.

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